Dubbed the most-complex structure in the universe, perhaps nothing is more mysterious, more enduringly elusive, than the human brain.  In the 19th century the ‘new science’ of phrenology promised to unlock the secrets of the human brain by studying the shape of a person’s head. A century later researchers started to look inside the skull for answers; the National Institutes of Health declared the 1990s the “Decade of the Brain” and federal money gushed into research grants, creating a renaissance in neuroscience. The results of that renaissance are just starting to emerge:  today’s brain imaging techniques allow scientists to map the neural circuitry of the human brain to within 50 nanometers; advances in brain-machine interfaces suggest a cyborg-like future may be closer to fact than fiction; and perhaps most importantly, modern paradigms of consciousness and behavior are emerging that suggest new insights into what makes us uniquely human. This week’s Friday Five looks at a small handful of projects and perspectives revealing the future of the brain.

Brainbow

The pictures look like stunning pieces of abstract art: vibrant multi-colored tendrils forming delicate branches of trees and tendrils.  Rather than an impressionist art exhibit, however, these pictures reveal brilliant bouquets of brain cells and are the highest resolution images of the brain available today.  Last year Dr. Jeff Lichtman and his team at the Harvard Brain Center developed transgenic mice with multicolored neurons using a new method that “paints” brain cells with a fluorescent protein, making visible individual neurons and their vast networks of connections.  Pictures of those mouse neurons, what Lichtman calls “Brainbows“, reveal an ethereal combination of technology and nature on the frontier of neuroscience. By color-coding neural circuits, researchers hope to create a complete a “wiring diagram” of the brain that will help identify the cause of neural disorders such as autism, schizophrenia and Alzheimer’s.  In this NPR interview, Lichtman describes the significance of brainbows for the future of neuroscience; for more eye candy, see this Wired gallery.

Augmented Cognition: DARPA goes Hollywood

DARPA’s Augmented Cognition program (”AugCog”) explores pathways to enhance human cognitive processes, particularly in the areas of attention and memory - a future-critical skill in a world increasingly characterized by information overload.   Most of the studies the agency funds have impenetrable-sounding titles, such as “Experience-Based Narrative Memory”.  But in this case, DARPA turned to Hollywood to bring the potential of augmented cognition technology to life.  The Future of Augmented Cognition is a short film directed by veteran filmmaker Alexander Singer that depicts DARPA’s vision of “AugCog” technologies in 2030.  Set in a command center tasked with monitoring cyberspace activities for anomalies that could threaten the global (and largely digital) economy, the film aims to provide both an entertaining and informative overview of the role AugCog technology could play in everyday life in the future.

Brain-machine interface

In 2001, electrician Jesse Sullivan accidentally touched a live cable, electrocuting him with 7,500 volts of electricity. As a result, both his arms were amputated at the shoulder. In the process of fitting him for artificial limbs surgeons took the severed ends of the nerves that once controlled Sullivan’s arm and rerouted them to the muscles in his chest. Unexpectedly, the nerves grew into the muscles and the procedure made Jesse Sullivan the first person to receive a nerve-muscle graft and use it to control an artificial limb. While there are numerous stories in the news today about the potential of brain-machine interfaces, this video from Pop!Tech 2005 tells one of the most remarkable and inspiring stories in neuroscience.

Promise and Peril: The Future of the Brain

The title says it all.  Most books about the future of the brain tend to be either science-heavy or buried in a deep layer of philosophical theory covering the dualism vs. holism debate.  Scientist and author Steven Rose balances the approach in Promise and Peril: The Future of the Brain, an ethically-aware, pop-sci look at how developments in neuroscience (including smart pills, brain repair and mind-reading devices) will change our understanding of what it means to be human in the future. 

Blue Brain 

The human brain is often described as a biological supercomputer, and the holy grail of computing has long been to make a machine that functions with the speed, accuracy and complexity of a human brain. But can a brain be built from a bunch of circuit boards and microchips?  IBM and Swiss research lab EPFL say yes: they’ve teamed up to create the Blue Brain project, described as the first comprehensive attempt to reverse-engineer the mammalian brain.  Blue Brain, as the supercomputer is called, consists of 2,000 microchips, each of which has been programmed to act like a neuron in a human brain and which together replicate “with shocking precision” the cellular events unfolding inside a mind. This SEED magazine article by science writer Jonah Lehrer offers an in-depth look at road to building Blue Brain, from the eccentric personalities (including project leader Henry Markam) to the technical hurdles (such as an estimated annual $3 billion electric bill).

If you could have one superhuman power, what would it be? 

Admit it: we’ve all harbored some fantasy about what it would be like if we could fly or walk through walls or move objects just by looking at them. The wildly popular tv show Heroes taps into our inner superhuman desires, telling the stories of ordinary people who discover that they have superhuman abilities (including a cop who can read minds and a cheerleader who can heal herself). How closely does fantasy mimic reality?  Turns out pretty closely, in some cases.  The heroes on the show gained their powers via a genetic mutation, but several superhuman abilities are within reach, mainly thanks to some well-funded military research. This week’s Friday Five explores future superpowers we can look forward to, and what they might mean for society.

Bionic Eyes

This Discover article reports that engineers at the University of Washington are developing contact lenses that contain electronic circuits that would allow wearers to see information superimposed over their view of the world in front of them (such as driving control panels and immersive virtual games) and “surf the Internet on a midair virtual display screen that only they would be able to see.”  Someday, the lenses might also offer tele/microscopic vision, the ability to see infrared frequencies, or the ability to take pictures and videos.

Super Strength

From the Incredible Hulk to Superman, the ability to pick up large objects (such as cars and meteoroids) seems to be the most common attribute of superheroes.  So it’s no surprise the military is investing heavily in giving its soldiers super human strength.  Defense Advanced Research Projects Agency (DARPA) is first in line, developing an exoskeleton - a frame that fits over the body designed to help soldiers move faster and farther, carrying heavier loads and weaponry.  The key?  The robotic frame contains miniature internal combustion engines moving each powered joint.  This New Scientist article provides an update on the research, which is expected out sometime this year.

New Limbs

This much-watch video from IEEE Spectrum showcases Dean Kamen’s “Luke Arm”, a robotic arm named after Luke Skywalker’s mechanical hand in Star Wars.  It’s amazing footage of a emerging vison of next-generation limb prostheses that are fully functional, neurologically controlled, and have normal sensory capabilities.  More than that, it’s also incredibly inspiring: the soldiers featured testing the arm (some of whom are double amputees) talk about the feelings of liberation and independence the arm is giving them.

Mind Reading

Perhaps the most potent (and the most controversial) of future superpowers is the ability to read minds.  Psychics claim that this is an inherent ability, but science is taking another approach: last year researchers used high-resolution brain scans to identify patterns of activity before translating them into meaningful thoughts, revealing what a person planned to do in the near future.  While the ability to truly read minds is likely still decades away, the brain scan technology is also driving developments in human-computer interfaces such as mind-controlled computers that would allow people to operate email and the internet using thought alone.  Check out this Guardian article for more.

Super Humans

Joel Garreau’s best-selling book Radical Evolution: The Promise and Peril of Enhancing Our Minds, Our Bodies — and What It Means to Be Human discusses the implications of human enhancement.  In the future, how will “Natural” and “Enhanced” children compete in school?  In life? I’ve argued that we’re on the verge of a socially fracturing debate about what it means to be human; Garreau explores how this debate will affect us at every level. It’s a great read, one that will change what you thought you knew about the future.